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Why Personalized Trials


Managing hidden triggers in the real world


Patients with autoimmune diseases often are able to use one or more prescription therapies called immunosuppressants to gain control of their disease flares. Such therapies have made great strides in helping patients improve their quality of life by reducing the immune system's response to triggers hidden in their exposome.

Non-responders to such therapies remain vulnerable to the complex variables that make up their exposome. Their immune system continues to inflame and attack different cell types throughout their body, resulting in such uncontrolled symptoms as pain and inflammation in multiple joints, weakness, brain fog, digestive issues, sleep disorders, headaches and more. 

What is a non-responder?

A non-responder is someone who cannot tolerate their prescribed immunosuppressant or sees only minimal improvement in rheumatic symptoms, like joint pain or stiffness despite treatment. On average 40% of patients in randomized controlled trials are non-responders.

What is the exposome?

The exposome represents the totality of all internal biological and external environmental factors individuals are exposed to throughout their life. Such factors can include diet, sleep, stress, air and water quality, climate and exposure to mold, toxins, pathogens or UV light.

No two exposomes are the same, not even with identical twins.

It can be a perfect storm of triggers that lead to a deterioration in health. The type, timing and frequency of exposures to potential triggers all play a role.


Managing flares through trial & error


For people with unpredictable and debilitating symptoms, trial & error between additional medications, supplements and diets can lead to even more exposure to hidden triggers, with no way to know what helps and what hurts.

Understanding how hidden triggers, cross-reactivities, and interactions  in the exposome, directly impact one's own symptoms, is critical to preventing and managing flares.

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How it Works


From trial & error to personalized trial & care


Mymee replaces the difficult and often dangerous trial & error process with personalized trial & care.

A self-evidence-based approach is critical to being able to directly correlate symptoms to unique triggers hidden within the exposome.

Mymee pairs each patient with a certified personalized trial coach who guides every step of the process with one-to-one support. 

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One-to-One Support


Mymee Coach Expertise

Mymee coaches are certified health and nutrition experts trained on Mymee’s proprietary personalized trial & care platform to analyze unique trigger-symptom correlations and guide each person through their own personalized trial process.

Each coach has experience reclaiming their own health from autoimmune disease and brings deep knowledge and training helping patients gain control of unpredictable flares.

Mymee personalized trial & care expertise:

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Mymee is HIPAA compliant and SOC-2 audited.  

If you are looking for specialized support to reduce symptoms and control flares, please contact us directly for a free consultation with a Mymee coach.

Outcomes & Research

Who may benefit from personalized trials

Mymee’s personalized trial & care platform is clinically validated for patients with unmanageable symptoms and complex sensitivities to their exposome, resulting from ≥1 autoimmune disease or long COVID. 

Enrolled patients reported a mean improvement across 59 patient-reported symptoms of 40% in an average of 17 weeks. 

Patients with moderate to severe symptoms achieved statistically significant and clinically meaningful improvement across all ten HRQoL PROMIS domains.

In peer-reviewed studies of personalized trials, the mostly commonly reported symptoms at enrollment included*: 

  • Fatigue
  • Pain & aches in joints
  • Limitation of movement
  • Feeling of weakness 
  • Pain or cramps in muscles
  • Diarrhea and/or constipation
  • Night waking
  • Brain fog (poor memory, confusion)
  • Anxiety
  • Headaches
  • Faintness/dizziness
  • Numb or tingly sensation
  • Intestinal or abdominal pain
  • Breathing difficulties
  • Tremor or restless leg

The most frequent diseases in the studies included: 

  • Rheumatoid Arthritis
  • Lupus (SLE)
  • Psoriatic Arthritis
  • Ankylosing spondylitis
  • Long COVID
  • Mixed connective tissue disease
  • Crohn’s and ulcerative colitis plus rheumatic symptoms
  • Psoriasis plus rheumatic symptoms
  • Multiple sclerosis plus rheumatic symptoms


Additional research and analysis has demonstrated that personalized trials and care with Mymee has enabled patients to:

  • Improve their ability to work with their doctor to manage symptoms

  • Achieve statistically significant improvements in ten health-related quality of life (HRQoL) domains such as fatigue, pain, anxiety and cognitive function

  • Improve their feelings of hopelessness by an average of 75%

*Sources: 1. Peer-reviewed study of personalized trials in autoimmune population, Rheumatic & Musculoskeletal Open Journal, May 2023; 2. Symptoms-59 survey, weighted mean change (n=182 personalized trials); 3. A Self-Evidence-Driven Personalized Trial and Care Program Correlates the Exposome to Persistent Autoimmune Rheumatic Symptoms and Improves Health-Related Quality of Life; (n=163 personalized trials); poster, IMF conference, 2023.

Mymee’s specialty is working with individuals who


Have one or more diagnosed rheumatic autoimmune diseases such as Lupus, RA, Ankylosing Spondylitis, Psoriatic Arthritis or Mixed Connective Tissue Disease


Report active joint pain & other systemic rheumatic symptoms associated with rheumatic long COVID & autoimmune diseases like Psoriasis, Inflammatory Bowel Disease or Hashimoto's


Managing > 10 unique unpredictable symptoms, not unusual with long COVID & mixed autoimmune disease diagnosis


Are adhering to presciption NSAIDs, steroids, conventional and/or biologic DMARDS & still experiencing disease flares


Already tried supplements, autoimmune diets & removing gluten, and are still managing significant unpredictable sysmptoms


Are at a crossroads with their treatment & working with their doctor to decide what's next

Clinically proven, personalized to the individual

Please contact us to request additional information about Mymee's clinically-validated personalized trial & care platform, proprietary custom data insights or peer-reviewed published studies.